Do you suffer from Stress, Anxiety & Burnout?

Anxiety and Stress

Magnesium is extremely important for mental and neurological health. Studies have shown that magnesium deficiency causes stress & anxiety. Stress causes you to excrete more magnesium through urine Therefore, being deficient can create anxiety and burnout.

Magnesium supplementation has been shown to promote a healthy stress response and reduce neurotransmitters that cause anxiety. It also promotes relaxation by stimulating GABA, the calming neurotransmitter.

What does GABA do to the human body?

GABA, also known as gamma-aminobutyric acid, is a natural chemical produced by the brain. It is a valuable anti-anxiety neurotransmitter. When we experience stress, the adrenal glands are triggered to produce hormones that trigger what we know as fight-or-flight responses, like speeding up your heartbeat or giving you an adrenaline rush.

REF: www.webmd.com/diet/health-benefits-gaba

In a randomized controlled trial of mildly anxious subjects, magnesium + vitamin B6 significantly reduced stress scores compared to the placebo.

Magnesium supplements have also been shown to help improve mental health in women with premenstrual syndrome and postpartum anxiety.

To boost mood, reduce anxiety, and promote a healthy stress response, it is best to use a combination of forms of magnesium combined with vitamin B6. Studies have confirmed that magnesium with organic acid salt (e.g. citrate and malate) or amino acids (e.g. taurate, glycinate, and sucrosomial) are significantly better absorbed than inorganic salts (oxide, chloride, and sulfate). Also, these different forms are absorbed into different tissues, with taurate, malate, and citrate being the most beneficial for the nervous system.

Stress & Burnout

Stress

Magnesium is one of the most important minerals for all aspects of health. It participates in over 600 different biochemical reactions in your body. Yet, over 80% of the population don’t get the minimum amounts of the types of magnesium they need from diet alone because the soil lacks it. Magnesium deficiency can increase all disease risks and keep you from performing optimally.

Magnesium content in vegetables has declined up to 80% since 1950 and modern processing of grains for flour and pasta removes 80-90% of total magnesium. No wonder we are now being told that we have to eat 10 portions of fruit and vegetables a day to remain healthy!

Even people who supplement tend to take types that are poorly absorbed, or they only take two types of magnesium at most. Each type benefits different tissues and organ systems. If you’re only taking one or two forms, you’re most likely still deficient.

Why Getting ALL 7 Forms of Magnesium Transforms Your Stress & Performance

One of the biggest misconceptions about magnesium is that you just “need more” of it and you’ll be healthy and optimized.

But the TRUTH is, there are many different types of magnesium — and each plays a critical role in different functions in your body.

7 Forms of Magnesium

Most “healthy” people only get 1-2 forms at best (much of the population is deficient in all forms) — but when you get all 7 major forms of magnesium, that’s when the magic happens.

Magnesium Chelate
Magnesium Bisglycinate
Magnesium Malate
Magnesium Sucrosomial
Magnesium Taurate
Magnesium Orotate

Why Magnesium Breakthrough

Magnesium Breakthrough

Magnesium Breakthrough

£29.99 – £74.99

Clear

BiOptimizers Magnesium Breakthrough contains the full spectrum of all seven forms of the most bioavailable magnesium along with vitamin B6 to support mental health and promote a healthy stress response.

BiOptimizers Magnesium Breakthrough is the only supplement on the market that offers the full spectrum of all seven types of magnesium specially formulated to reach every tissue in your body to provide maximum health benefits and reverses low levels which could be causing health issues.

Getting ALL of these forms of magnesium, in the optimum dose, upgrades virtually every function in your body.

Magnesium table

The #1 Best Way To Experience The Researched Benefits of Magnesium

Magnesium has more researched benefits than any other nutrient — and more studies to back up its claims than any other.

To date, over a thousand studies have been conducted on magnesium.

These studies have concluded that magnesium helps you:

  • Magnesium helps move blood sugar into your muscles and dispose of lactate, which can build up in muscles during exercise and cause pain 
  • Supplementing with it can boost exercise performance for athletes, the elderly and people with chronic disease 
  • In one study, volleyball players who took 250 mg of magnesium per day experienced improvements in jumping and arm movements 
  • Athletes who supplemented with magnesium for four weeks had faster running, cycling and swimming times during a triathlon. They also experienced reductions in insulin and stress hormone levels 
  • Magnesium plays a critical role in brain function and mood, and low levels are linked to an increased risk of depression 
  • Supplementing with this mineral may help reduce symptoms of depression — and in some cases, the results can be dramatic 
  • In a randomized controlled trial in depressed older adults, 450 mg of magnesium daily improved mood as effectively as an antidepressant drug. 
  • One study which followed more than 4,000 people for 20 years found that those with the highest magnesium intake were 47% less likely to develop diabetes 
  • People with type 2 diabetes taking high doses of magnesium each day experienced significant improvements in blood sugar and hemoglobin A1c levels, compared to a control group. 
  • In one study, people who took 450 mg per day experienced a significant decrease in systolic and diastolic blood pressure. 
  • Magnesium supplements can reduce CRP and other markers of inflammation in older adults, overweight people and those with prediabetes. 
  • A few encouraging studies suggest that magnesium can prevent and even help treat migraines. 
  • Supplementing with 1 gram of magnesium provided relief from an acute migraine attack more quickly and effectively than a common medication. 
  • Magnesium plays a crucial role in preventing insulin resistance, and many people with metabolic syndrome are deficient. 
  • Magnesium improves insulin resistance. 
  • One study found that supplementing with this mineral reduced insulin resistance and blood sugar levels, even in people with normal blood levels. 
  • Magnesium has been shown to improve mood, reduce water retention and other symptoms in women with PMS. 

Magnesium Breakthrough

Magnesium Breakthrough

Magnesium Breakthrough

£29.99 – £74.99

Clear

BiOptimizers Magnesium Breakthrough contains the full spectrum of all seven forms of the most bioavailable magnesium along with vitamin B6 to support mental health and promote a healthy stress response.

Scientific Studies

  1. de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
  2. DiNicolantonio JJ, Liu J, O’Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775
  3. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  4. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
  5. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047
  6. Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067
  7. Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661
  8. Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223.
  9. Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7
  10. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136.
  11. Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855
  12. Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003;26(4):1147-1152. doi:10.2337/diacare.26.4.1147
  13. Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498
  14. Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616
  15. Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance?. Nutrients. 2017;9(9):946. Published 2017 Aug 28. doi:10.3390/nu9090946
  16. Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927
  17. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
  18. Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022
  19. Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488
  20. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664
  21. Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197. doi:10.1038/sj.ejcn.1601689
  22. Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614.
  23. Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994
  24. Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742
  25. Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
  26. Sartori SB, Whittle N, Hetzenauer A, Singewald N. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027
  27. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
  28. Grases G, Pérez-Castelló JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006;19(2):102-106.
  29. Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411
  30. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  31. Caillard, V. (1992). Sanofi Internal report MAB6-32. Paris, France. Unpublished work.
  32. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  33. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
  34. Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L. Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine. Magnes Trace Elem. 1990;9(5):272-278.
  35. Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262.
  36. Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187(1):128-136. doi:10.1007/s12011-018-1351-9
  37. Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538
  38. Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.
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