
Why Is Berberine Breakthrough The Best?
- Synergy of science-backed blood sugar control ingredients at doses shown to be clinically effective
- The formula addresses all biochemical pathways contributing to blood sugar control
- Tested to potently help normalize blood sugar response
- Designed to help enjoy your favourite high-carb foods
- 100% natural and drug-free


Blood Sugar Rollercoaster
Most people nowadays have some trouble with poor blood sugar balance from stress, inactivity, and suboptimal sleep. As a result, after a high-carbohydrate meal, their blood sugar can rise very high and cause many healthy problems.
In the short term, the blood sugar dips cause energy crash, craving, fatigue, headache, dizziness, and “hangriness.” As a result, they may experience sugar cravings.
In the long term, the blood sugar roller coasters can cause your cells to become resistant, and may lead to belly fat, metabolic syndrome, cardiovascular diseases, and many more issues.
One way to stabilize is to create blood sugar balance by either eating fewer carbs or slowly absorbing carbohydrates.
Oxidative Stress
High blood sugar can increase oxidative stress, which ages your cells and creates inflammation. Hyperglycemia leads to the production of reactive oxygen species (ROS), which are highly reactive molecules that can damage cells and tissues. This imbalance between ROS production and antioxidant defenses is a key factor in the development and progression of many diabetes-related complications.
Weight Loss
Weight loss requires you to be in a caloric deficit, which means burning more than you eat.
- Balances chronic inflammation – Chronic inflammation from unhealthy diets (metabolic endotoxemia) can cause leptin resistance, which may lead to weight gain.
- Jumpstarts mitochondria – Many people who struggle with weight loss have sluggish mitochondria. Bitter melon extract can jumpstart the mitochondria by bringing fatty acids into the mitochondria, making fat burning more efficient. Also, by increasing a process called mitochondrial uncoupling, they use the energy to produce heat instead of for other cellular processes.
- Activates AMPK – AMPK is an energy sensor that activates fat burning. In Berberine Breakthrough, quercetin, berberine, ginsenoside Rb1, Alpha-lipoic acid, resveratrol, and cinnamon work together to activate AMPK.
Overall, stabilizing blood sugar typically reduces the hunger, cravings, and moodiness that arise during blood sugar lows. You will also reduce your cortisol due to lower stress levels, making it easier to lose fat from the abdominal area. This should make it easier to stay on a healthy and caloric-deficit diet.
Supports Healthy Hormone Balance and Stress Response
Constantly being on blood sugar rollercoasters is very stressful to the body because the blood sugar lows put your body in an emergency response mode. When your body is in a fight or flight mode, your hormones, regenerative, and reproductive functions go on the backburner.
Therefore, poor blood sugar control can cause hormone imbalances, worsening symptoms such as PMS, hot flashes, and low libido.
It is critical to improve your blood sugar control if you want to balance your hormones and have a healthy stress response.
Supports Good Mood and Healthy Brain Function
Your brain controls not only your thoughts but also many aspects of your physiology on autopilot. This takes a lot of glucose. It weighs 2% of your bodyweight but takes up to 20% of your daily calorie intake.
As a result, your brain is exquisitely sensitive to major blood glucose fluctuation. Extreme blood sugar fluctuations can worsen anxiety, irritability, depression, brain fog.
Anti-Aging
Glucose is a type of oxidizing sugar, which means high blood glucose can increase oxidative stress and accelerate aging. If you want to live a long and healthy life, you want to keep your blood sugar even-keeled. increased glucose levels in the bloodstream, especially due to high sugar intake, can contribute to the aging process, particularly affecting skin health.
This happens through a process called glycation, where sugar molecules bind to proteins in the skin, leading to the formation of Advanced Glycation End products (AGEs). AGEs damage collagen and elastin, the proteins that keep skin firm and elastic, causing wrinkles, sagging, and other signs of aging.

















Inita Drava (verified owner) –
Great for occasional use. Love this product – I don’t use it every day but scenarios when I accidentally or purposely had too much sugar on an empty stomach, these help like a dream to not let my mood drop. Helps me also on hot summer days with my hunger cues due to heat. Thank you!
Ann Roodt (verified owner) –
I used to feel hungry after having a HUGE meal.. I used to often feel hungry after having had a HUGE meal, and I sometimes felt my blood sugar drop between meals during the day. I have always eaten healthy, been reasonably fit and never been overweight. There is type 2 / B diabetes in my family, therefore I have been looking after my health for most of my life.
Since I started taking —> one <— 'Blood Sugar Breakthrough' capsule in the morning with breakfast, the 'starving after a big meal' feeling is gone and I have not felt my blood sugar drop between meals. I have been taking these capsules for roughly four months.
Morgan –
Be careful. I started using it soon after arrival. I eat a fairly healthy diet; protein, greens/fruits, and I’m moving away from gluten. After taking it once a day, my stomach was destroyed…for over 24 hours. I had to back the dosage down to one pill every other day and it’s still ify. I love all the other Bioptimizers products, but I would use caution with this one.
Ravi Soni –
. Blood Sugar Breakthrough
Anna C. –
I love Berberine Breakthrough. I don’t have a lot of sugar but when I do I love knowing I have this product to keep my blood sugar levels normal.
Anna C. –
I love Blood Sugar Breakthrough. I don’t have a lot of sugar but when I do I love knowing I have this product to keep my blood sugar levels normal.
Alice Rose –
So sweet. So far this product has been brilliant for me
and seems to stop me wanting a dessert after lunch!
ealfaro –
The missing puzzle piece to my life. I cannot say good enough things about this product. This truly was the missing puzzle piece to my life. I haven’t been taking this product for long I barely got it last Saturday and it is now may 4th and I can say that just from the short time span that I have been taking it, it’s made a huge difference! I used to wake up moody and hungry and that mood would continue throughout my day. I always felt tired, foggy, low motivation to do anything because of the fatigue. A huge lack of labido and I’m young! But I can say that after taking blood sugar breakthrough my life has changed for the better!! I have stable moods all day, I’m not as hungry and am easily satiated with what I eat so cravings are a lot less now. My labido has been amazing! And also I have been able to relieve some constipation with this and I now have much better elimination than before and I don’t feel so bloated anymore! Just THANK YOU!!! Thank you so much for all your hard work on this product, it really makes the $75 worth it!! <3
Ealfaro –
The missing puzzle piece to my life. I cannot say good enough things about this product. This truly was the missing puzzle piece to my life. I haven’t been taking this product for long I barely got it last Saturday and it is now may 4th and I can say that just from the short time span that I have been taking it, it’s made a huge difference! I used to wake up moody and hungry and that mood would continue throughout my day. I always felt tired, foggy, low motivation to do anything because of the fatigue. A huge lack of labido and I’m young! But I can say that after taking berberine breakthrough my life has changed for the better!! I have stable moods all day, I’m not as hungry and am easily satiated with what I eat so cravings are a lot less now. My labido has been amazing! And also I have been able to relieve some constipation with this and I now have much better elimination than before and I don’t feel so bloated anymore! Just THANK YOU!!! Thank you so much for all your hard work on this product, it really makes the $75 worth it!! <3
Brandi J. –
Keto. If you are doing keto these help me get back into ketosis quicker after sugars/carb intake.
Kathe O. –
I think it worked very. I think it worked very well.
Abdel F. –
Excellent product. Excellent product
Vince –
Benefits from day 1. First day I took it in the morning before work, and noticed my energy level was constant for the whole day. Love this product!
Rhonda W. –
well tolerated and it works. Took 1/2 a dose last night before dinner and this morning my BG was down 40 points. And I’m on prednisone! Even on strict keto I haven’t been able to get my HbA1C below 5.4 (pre-prednisone). I would love to rachet it down more and this is the first product I’ve tried that actually works and doesn’t make me feel super groggy and tired. I’ll set up a subscription when I make my way through this bottle. Thank you for a quality product that gives great results.
Bonnie H. –
Blood sugar. This is the only product that consistently brings my glucose level down by 10.
Martha V. –
Love that I have something. Love that I have something to take during a “carb/cheat day†that actually works!
David R. –
Great glucose disposal agent. Seems. Great glucose disposal agent. Seems to work very well. Will know more after 60 days.
Marie P. –
great product. great product
Pete C. –
Love all three and will. Love all three and will be reordering.
Joseph –
Haven’t used long enough to. Haven’t used long enough to know how effective it is
Marny S. –
Felt it’s effect immediately. In my mid 40’s and struggling with sluggish digestion and questioning my food choices. When I remember to take this supplement 20 minutes before a meal I feel great and can have more freedom with what I choose to eat.