A nootropic blend that improves brain health, mental clarity, learning, memory and focus by improving the gut bacteria.
• Helps with brain fog and procrastination.
• Promotes relaxation and balanced stress responses.
• Contains 17 nootropic and adaptogenic herbs that boost cognitive function, mood and stress resilience by improving your gut flora.
• A powerful synergy of 10 brain-friendly probiotic bacteria strains, which have been shown to boost mood and cognitive function.
• Improves the balance of neurotransmitters, including acetylcholine, serotonin, GABA and dopamine in the brain.
• Improves neuroregeneration and neuroplasticity by improving BDNF and NGF which boost learning capacity and mood.
• Protects the brain against oxidative stress.
• Improves blood flow to the brain.
• Supports digestive health and regularity.


Take 1-2 caps of Cognibiotics first thing in the morning on an empty stomach. Some people also find significant cognitive and mood boosts when they take CogniBiotics before or with lunch and dinner.

The goal is to deliver the probiotics to your large intestine relatively intact and maximize absorption of the herbs, so you want to minimize their exposure to your stomach acid and digestive enzymes. Your gut secretes digestive enzymes and stomach acid when you have food in your stomach. Therefore, you should take your CogniBiotics on an empty stomach. However, if you get stomach upset from taking it without food or cannot take it without food for any other reasons, it is still beneficial when taken with meals.

Because CogniBiotics contain probiotics, be sure to take it at least an hour away from antibiotics or dietary supplements that have antibacterial properties.

CogniBiotics and Depression

The latest research shows that, aside from life events, the following factors contribute to depression,[16] cognitive dysfunction, and other mental health problems:

  • Imbalanced gut microbiome
  • Sluggish neurons in the brain due to mitochondria dysfunction[17]
  • Overactivated stress response[18]
  • Increased inflammation[19]
  • Intestinal permeability[20]
  • Abnormal circadian rhythm or sleep patterns[21]
  • A leaky blood-brain barrier[22]
  • Unstable or poor blood sugar control[23]
  • Nutrient deficiencies,[24] such as omega-3, B vitamins, minerals, and amino acids

CogniBiotics promotes good mood, mental health, cognitive function, and stress resilience by:

  • Improving the gut microbiome
  • Energizing the neurons
  • Promoting a balanced immune response
  • Supporting the gut and brain barriers
  • Promoting digestive health
  • Supporting blood sugar control 

Most nootropics and adaptogens only target the brain, which leaves out the key pieces of your cognitive function and mental health: your gut and the gut microbiome. CogniBiotics is the only probiotic-nootropic blend on the market that improves the entire gut-brain-microbiota axis.

The formula contains a powerful combination of 17 herbs known provide mood support and enhance cognitive function by improving the gut microbiome.[1] In addition, the 10 bacteria strains in CogniBiotics work synergistically to boost brain health and promote a balanced stress response.

  • Formulated by expert Chinese Herbal Scientists
  • The 2,200-year-old Chaihu-Shugan-San herb blend improves mood, brain health, and happiness through the gut microbiome
  • 10 research-based bacteria strains that synergize to improve mood and cognitive function
  • Prebiotic complex boosts probiotic survival and effectiveness
  • Adaptogenic: calming, promotes a balanced-stress response from the nervous system and mitigates negative health effects of stress
  • Nootropic: boost memory and learning, and maintain healthy brain function amidst stress
  • Improves mood and happiness
  • Protects the brain with antioxidants that can enter the brain
  • Supports neuroplasticity, which improves brain adaptation and healing
  • Can be taken on an empty stomach or with meals
  • 100% Satisfaction guarantee with respect to quality, purity, potency, and effectiveness
  • Produced in small batches with medical-grade ingredients.

Serving Size: 1-2 caps

60 caps per bottle.

Product Dimensions:

Lid diameter: 1.58 inches

Bottom diameter: 1.95 inches

Height: 3.78 inches

Weight: 1.98 ounces

Made in the USA.

Suitable for vegetarians.

Store in a cool/dry place away from direct light.



Nutritional Facts

CogniBiotics® contains all of the strains you need to
positively transform your second brain and:

  • Boost BDNF (Brain-Derived Neurotrophic Factor)
  • Boost low mood, reduce anxiety
  • Reduce stress
  • Produce mood-boosting vitamins (e.g. K and B-12)
  • Rejuvenate your brain and improve brain-gut connection
  • Generate serotonin and happiness chemicals
  • Enhance cognitive performance
  • Suggested Use

    Start with 2 a day, taken upon
    awakening on an empty stomach.


Keep out of reach of children. As with
any product, discontinue immediately
if advert effects occur. Please consult
a physician before beginning any new
supplement, diet, training program,
or if you’re undergoing treatment of a
medical condition.


1 Bottle, 2 Bottles, 3 Bottles

Customer Reviews

Based on 5 reviews
Michelle Hagan
Tried for one month

I took 2 caps each morning on an empty stomach, sorry but I didn't notice any difference. Won't be buying again.

Lucas Mostyn


Fritz Kohlhoff

Excellent product

Will Grover
It works!

After just a few days, I already feel an improved mood and general mental function. Thanks Bioptimizers!

Nicola Potts
excellent product

Has helped change gut and brain issues when all else over many years of trying many products has failed. And results can be felt within days. Couldn't recommend this product more.

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