bioptimizers brain health

Do you suffer from Brain Fog or Mental Fatigue?

Brain fog and lack of mental clarity can be major obstacles and sources of frustration in our journey to optimal health and peak performance. Whether we want to give our best at work, or simply enjoy the fullness of life, being unable to focus on our goals or the tasks at hand interferes with our ability to be present and achieve success.

7 Science-Proven Ways The Right Brain Supplements Support Brain Health

1. Beating Brain Fog By Optimizing The Gut-Brain-Microbiome Axis

bioptimizers brain fog support

Brain fog, memory issues and difficulty concentrating are easily mistaken with being absent-minded or simply lazy. In reality, they’re more often signs of improper communication between brain cells. Chemicals known as neurotransmitters are responsible for this communication, and the bacteria balance in our gut plays a key role in their production [4].

Research has shown that improving the microbiome composition can be beneficial, even for people with neurological disorders [5]. But please note, Cognibiotics is not a substitute for medical treatment. Consult a physician before beginning any new supplement, diet, training program, or if you’re undergoing treatment of a medical condition.

2. Promotes Learning And Memory

bioptimizers brain health

Acetylcholine is an important neurotransmitter for learning and memory.

P. multiflorum, S. miltiorrhiza, and R. glutinosa in Cognibiotics increase acetylcholine levels [7].

Most brain supplements in the market contain ingredients that boost cognitive function, but these probiotics are like having a factory of positive neurochemicals in your own body.

3. Balance Your Stress Response

bitoptimizers stress supplements

Studies show [8] the probiotics L. plantarum, L. helveticus, L. fermentum, L. rhamnosus, and B. infantis promote the balance of serotonin, dopamine and GABA in the brain.

Well-balanced neurotransmitters will help to boost and sustain your mood, improve cognitive function, and support you in having a healthy stress response.

4. Helps Your Brain “Stay In Shape”

The brain is an organ. Like other organs, it is strengthened through consistent use and proper nourishment.

The good bacteria [9] and herbs [10] in Cognibiotics work together to stimulate the production of proteins that help the brain grow, reorganize, and adapt. Increasing these proteins helps with learning, memory and mood.

This is why Cognibiotics is one of the best brain health supplements for improving cognitive functions.

5. Helps Your Brain Stand The Test Of Time

bioptimizers brain health supplements

The herbal blends in Cognibiotics also help to protect neurons against oxidative stress.

Oxidative stress is an inevitable part of our daily routine. It comes from mental and emotional stress, environmental toxins, inflammation, unhealthy lifestyle, and more. We rarely consume enough antioxidants in our diets to withstand oxidative stress. This can contribute to brain cell damage, which may lead to brain fog, fatigue, and neurological aging.

Herbs in Cognibiotics contain antioxidants that can cross the blood-brain barrier and protect your brain from day-to-day oxidative stress [11].

6. Increases Blood Flow To The Brain

Your brain needs oxygen and vital nutrients to work well. Because it’s located at the highest point in your body and connects to many tiny blood vessels, it’s also the organ that’s hardest to deliver blood to. This reduced blood flow can translate to deprivation of proper oxygen and nutrients. This can cause fatigue, brain fog, poor memory, and low mood.

This reduced blood flow can translate to deprivation of oxygen and nutrients. This can cause fatigue, brain fog, poor cognitive function, and low mood.

The Chaihu-Shugan San herb formula normalizes brain blood flow [12] in patients with depression.

7. Producing Beneficial Substances From Probiotic Metabolism

bioptimizers brain health supplement

Among the benefits of probiotics is the generation of beneficial chemicals from their metabolism, “postbiotics”. One of the most well known is butyrate.

Low mood, brain fog, and fatigue [13] are caused by sluggish neurons that can’t produce enough energy (ATP). The small fatty acids like butyrate [14]can enter the brain, energize the sluggish neurons, and lower oxidative stress.

The small fatty acids also counteract chronic inflammation [15] and strengthen the gut and blood-brain barriers [16]. They also promote a healthy metabolism and blood sugar levels which are important for mental alertness.

What Is Brain Fog And How To Treat It?

Brain Fog

Not a medical condition

Brain fog is not a medical condition, but it can be a clinical manifestation of some medical conditions that relate to poor energy production in the brain. This may include:

  • Depression
  • Anxiety
  • ADHD
  • Anaemia
  • Hypothyroidism
  • Alzheimer’s disease
  • Autoimmune diseases
  • Obesity
  • Chronic fatigue syndrome and fibromyalgia
  • Infections and post-infection syndrome

Therefore, if you struggle with brain fog, you should see a doctor to rule out these potentially severe issues and get the appropriate treatments, such as taking BiOptimizers supplements for brain fog.


Brain fog is an ambiguous set of symptoms that indicate lagging brain function, such as:

  • Forgetfulness
  • Lack of focus or trouble concentrating
  • Inability to think clearly
  • Mental fatigue
  • Losing your train of thought mid-sentence
  • Forgetting words

These could be signs of aging or fatigue, but they are neither normal nor healthy. Otherwise, the chances are that you are probably experiencing brain fog.  Brain fog means your brain cells are struggling to produce enough energy to function optimally.

What Causes Brain Fog?

Your brain requires a lot of energy to function properly. It weighs 2% of your body weight but uses 60-70% of glucose.[iii] Each of your brain cells produces energy with the mitochondria, the cell’s energy powerhouse.

Any factor that prevents optimal energy production in the brain can contribute to brain fog. These may include:

  • High oxidative stress (stress to the body caused by the accumulation of free radicals) or inflammation
  • Lack of brain blood flow or oxygen delivery
  • Nutrient deficiencies

Therefore, the following factors can contribute to brain fog:

  • Poor Mitochondria Health
  • Low Oxygen Or Blood Flow To The Brain
  • Declining Mitochondria Function Associated With Aging
  • Poor Gut Health
  • Unhealthy Diet
  • Leaky Gut (Intestinal Permeability)
  • Gut-Brain Axis Alterations And Cognitive Impairments
  • Nutrient Deficiencies
  • Poor Sleep
  • Stress And Traumas
  • Medication And Recreational Drug Use

Cognibiotics – The Supplement To Fight Brain Fog!

Brain fog can be troublesome. The good news is that, in most cases, you can address the root causes and resolve them. Getting enough sleep, balancing your diet, getting enough rest after hard work, managing and controlling your stress, etc., are all effective ways to get rid of brain fog. 

Nootropic supplements can also help with brain fog by improving your brain’s mitochondria function, increasing brain blood flow, and counteracting oxidative stress. 

Cognibiotics supplements for brain fog are currently the only supplement on the market that supports the gut-brain axis and works as a nootropic. Studies show that the herb in Cognibiotics improves the gut microbiome, which helps with mood. 

Our formula results from a powerful combination of 17 herbs that support mood and cognitive function by improving gut microbiota. At the same time, the product also includes 10 bacterial species that work together to boost brain health and promote a balanced stress response.


  • A nootropic blend that improves brain health, mental clarity, learning, memory, and focus by improving the gut bacteria
  • Helps with brain fog and procrastination
  • Promotes relaxation and balanced stress responses
  • Boosts cognitive function, mood, and stress resilience by improving your gut flora
  • Improves the balance of neurotransmitters, including acetylcholine, serotonin, GABA, and dopamine, in the brain
  • Protects the brain against oxidative stress
  • Improves blood flow to the brain
  • Supports digestive health and regularity

The Benefits of CogniBiotics Probiotic Backed by Science

  1. Theoharides TC, Stewart JM, Hatziagelaki E, Kolaitis G. Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci. 2015;9:225.
  2. Berg JM, Tymoczko JL, Stryer L. Each Organ Has a Unique Metabolic Profile. W.H. Freeman; 2002.
  3. Kann O, Kovács R. Mitochondria and neuronal activity. Am J Physiol Cell Physiol. 2007;292(2):C641-57.
  4. Viscomi C, Zeviani M. Breathe: Your mitochondria will do the rest… if they are healthy! Cell Metab. 2019;30(4):628-629.
  5. Andreazza AC, Andersen ML, Alvarenga TA, et al. Impairment of the mitochondrial electron transport chain due to sleep deprivation in mice. J Psychiatr Res. 2010;44(12):775-780.
  6. Galkin A, Abramov AY, Frakich N, Duchen MR, Moncada S. Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury? J Biol Chem. 2009;284(52):36055-36061.
  7. Barry DI. Cerebral blood flow in hypertension. J Cardiovasc Pharmacol. 1985;7:S94-S98.
  8. Jochemsen HM, Muller M, Visseren FL, et al. Blood pressure and progression of brain atrophy: the SMART-MR Study: The SMART-MR study. JAMA Neurol. 2013;70(8):1046-1053.
  9. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203-209.
  10. Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264-276.
  11. Mawe GM, Hoffman JM. Serotonin signalling in the gut–functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2013;10(8):473-486.
  12. Jenkins TA, Nguyen JCD, Polglaze KE, Bertrand PP. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients. 2016;8(1):56.
  13. Cathomas F, Guetter K, Seifritz E, Klaus F, Kaiser S. Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder. Sci Rep. 2021;11(1):9992.
  14. Schultz A, Barbosa-da-Silva S, Aguila MB, Mandarim-de-Lacerda CA. Differences and similarities in hepatic lipogenesis, gluconeogenesis and oxidative imbalance in mice fed diets rich in fructose or sucrose. Food Funct. 2015;6(5):1684-1691.
  15. Hu Y, Costenbader KH, Gao X, et al. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women. Am J Clin Nutr. 2014;100(3):959-967.
  16. Iwata NG, Pham M, Rizzo NO, Cheng AM, Maloney E, Kim F. Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells. PLoS One. 2011;6(12):e29600.
  17. Mozaffarian D, Pischon T, Hankinson SE, et al. Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr. 2004;79(4):606-612.
  18. Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.
  19. Dixon LJ, Kabi A, Nickerson KP, McDonald C. Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis. Inflamm Bowel Dis. 2015;21(4):912-922.
  20. Oliveira A, Rodríguez-Artalejo F, Lopes C. Alcohol intake and systemic markers of inflammation–shape of the association according to sex and body mass index. Alcohol Alcohol. 2010;45(2):119-125.
  21. Bjarnason I, Ward K, Peters T. The leaky gut of alcoholism: Possible route of entry for toxic compounds. Lancet. 1984;323(8370):179-182.
  22. Wang HJ, Zakhari S, Jung MK. Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J Gastroenterol. 2010;16(11):1304-1313.
  23. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110(6):911-16.e12.
  24. Mu Q, Kirby J, Reilly CM, Luo XM. Leaky gut as a danger signal for autoimmune diseases. Front Immunol. 2017;8:598.
  25. Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut. 2006;55(10):1512-1520.
  26. Cimolai MC, Vanasco V, Evelson P, Bugger H, Alvarez S. Brain age-dependent effects of acute endotoxemia on oxidative damage and mitochondrial function. Biochim Biophys Acta Bioenerg. 2012;1817:S97.
  27. Liew KJ, Lim CC, Chan CS, et al. Direct cellulase gene amplification from hot spring using the guidance of 16S rRNA amplicon metagenomics. In: Metagenomics. Elsevier; 2018:309-325.
  28. Li B, He Y, Ma J, et al. Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota. Alzheimers Dement. 2019;15(10):1357-1366.
  29. Lanza G, Bella R, Cantone M, Pennisi G, Ferri R, Pennisi M. Cognitive impairment and celiac disease: Is transcranial magnetic stimulation a trait d’union between gut and brain? Int J Mol Sci. 2018;19(8):2243.
  30. Ihnatowicz P, Drywień M, Wątor P, Wojsiat J. The importance of nutritional factors and dietary management of Hashimoto’s thyroiditis. Ann Agric Environ Med. 2020;27(2):184-193.
  31. Valentine RC, Valentine DL. Omega-3 fatty acids in cellular membranes: a unified concept. Prog Lipid Res. 2004;43(5):383-402.
  32. de Oliveira MR, Nabavi SF, Nabavi SM, Jardim FR. Omega-3 polyunsaturated fatty acids and mitochondria, back to the future. Trends Food Sci Technol. 2017;67:76-92.
  33. Aloisi F. Immune function of microglia. Glia. 2001;36(2):165-179.
  34. Jaremka LM, Derry HM, Bornstein R, et al. Omega-3 supplementation and loneliness-related memory problems: secondary analyses of a randomized controlled trial. Psychosom Med. 2014;76(8):650-658.
  35. Jatoi S, Hafeez A, Riaz SU, Ali A, Ghauri MI, Zehra M. Low vitamin B12 levels: An underestimated cause of minimal cognitive impairment and dementia. Cureus. 2020;12(2):e6976.
  36. Nalder L, Zheng B, Chiandet G, Middleton LT, de Jager CA. Vitamin B12 and folate status in cognitively healthy older adults and associations with cognitive performance. J Nutr Health Aging. 2021;25(3):287-294.
  37. Menon V, Kar SK, Suthar N, Nebhinani N. Vitamin D and depression: A critical appraisal of the evidence and future directions. Indian J Psychol Med. 2020;42(1):11-21.
  38. Ceolin G, Matsuo LH, Confortin SC, D’Orsi E, Rieger DK, Moreira JD. Lower serum 25-hydroxycholecalciferol is associated with depressive symptoms in older adults in Southern Brazil. Nutr J. 2020;19(1):123.
  39. Penckofer S, Byrn M, Adams W, et al. Vitamin D supplementation improves mood in women with type 2 diabetes. J Diabetes Res. 2017;2017:1-11.
  40. Cheng Y-C, Huang Y-C, Huang W-L. The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis. Depress Anxiety. 2020;37(6):549-564.
  41. Razzaque MS. Magnesium: Are we consuming enough? Nutrients. 2018;10(12):1863.
  42. Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician. 2009;80(2):157-162.
  43. Katz MJ, Derby CA, Wang C, et al. Influence of perceived stress on incident amnestic mild cognitive impairment: Results from the Einstein Aging Study. Alzheimer Dis Assoc Disord. 2016;30(2):93-98.
  44. Jonsdottir IH, Nordlund A, Ellbin S, et al. Cognitive impairment in patients with stress-related exhaustion. Stress. 2013;16(2):181-190.
  45. Tobe EH. Mitochondrial dysfunction, oxidative stress, and major depressive disorder. Neuropsychiatr Dis Treat. 2013;9:567-573.
  46. Atrooz F, Salim S. Sleep deprivation, oxidative stress and inflammation. Adv Protein Chem Struct Biol. 2020;119:309-336.
  47. Nir Y, Andrillon T, Marmelshtein A, et al. Selective neuronal lapses precede human cognitive lapses following sleep deprivation. Nat Med. 2017;23(12):1474-1480.
  48. Gong Y, Chai Y, Ding J-H, Sun X-L, Hu G. Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett. 2011;488(1):76-80.
  49. Manji H, Kato T, Di Prospero NA, et al. Impaired mitochondrial function in psychiatric disorders. Nat Rev Neurosci. 2012;13(5):293-307.
  50. Marieb EN, N. R. Human anatomy & physiology ninth edition. Accessed November 10, 2021.
  51. Understanding the stress response. Published July 6, 2020. Accessed November 10, 2021.
  52. Chyun YS, Kream BE, Raisz LG. Cortisol decreases bone formation by inhibiting periosteal cell proliferation. Endocrinology. 1984;114(2):477-480.
  53. McAuley MT, Kenny RA, Kirkwood TBL, Wilkinson DJ, Jones JJL, Miller VM. A mathematical model of aging-related and cortisol induced hippocampal dysfunction. BMC Neurosci. 2009;10(1):26.
  54. Braveman P, Gottlieb L. The social determinants of health: it’s time to consider the causes of the causes. Public Health Rep. 2014;129 Suppl 2(1_suppl2):19-31.
  55. Tannenbaum C, Paquette A, Hilmer S, Holroyd-Leduc J, Carnahan R. A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs Aging. 2012;29(8):639-658.
  56. Thayer RE, YorkWilliams S, Karoly HC, et al. Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults. Addiction. 2017;112(12):2144-2154.


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